Optogenetics has become an important research tool in neuroscience for its high temporal and spatialresolution and cell specificity. The traditional optogenetic solution is to transmit specific wavelength of light to the target nuclei through optical fibers. This wired connection interfere with the behavioral results of experimental animals more or less, limiting the regulation of light stimulation in some behavioral paradigms. However, as the optogentics goes deeper and broader in research fields, such as peripheral nerves, heart, skin, urinary system, etc., traditional solutions by fiber implantation become increasingly difficult to meet the actual experimental demands. Therefore, miniaturization, wireless, and flexible optogenetic solutions are almost certain.