光遗传系统示意图
Inper offers a variety of implantable fiber optic cannula for Optogenetics and Photometry. The fiber optic cannula consists of a ceramic or metal ferrule and a length of bare fiber. With the aid of a stereotaxic device, the fiber optic cannula can be implanted into the target nerve nuclei, and fixed on the skull with dental cement and screws. The fiber optic cannula can be connected to the optogenetic fiber via a matched mating sleeve to transmit the light from the LED or laser source to the target nerve nucleus, and then regulates the activity of neurons.
Two sizes of cannulas for meeting different experimental requirements
Inper offers two sizes of fiber optic cannulas with Ø1.25 mm or Ø2.5 mm ferrules.
The fiber optic cannula with Ø1.25mm ferrule has a small size and light weight, making it ideal for small laboratory animals, or multiple stimulation or fiber recording within a small area of an experimental animal.
The fiber optic cannula with Ø2.5mm ferrule is more conducive to surgical operation, and the connection between dental cement and experimental animals will also be stronger, suitable for large experimental animals, or a single point of stimulation or fiber recording.
Choice of NA
The numerical aperture (NA) is the ability of the end face of the fiber to accept light and also determines the angle at which the light is emitted from the fiber.
In experiments, the smaller the NA, the smaller the angle at which light is emitted from the fiber and the smaller the irradiated area, that is, the smaller the area of the nerve nuclei controlled by light. The larger the numerical aperture, the larger the angle at which light is emitted from the fiber and the larger the irradiated area, that is, the larger the area of the nerve nuclei controlled by light.
In optical fiber recording experiments, large numerical apertures can acquire more fluorescence signals.
Inper offers a variety of fiber options with different numerical apertures. The incident and emission angles for different NA are shown in the figure above (Fiber-Air Interface).
Specifications for 插芯针（黑色）
| 插芯尺寸（mm） | 1.25 or 2.5 |
| 光纤长度（mm） | 0.5 or 1 or 1.5 or 2 or 2.5 or 3 or 3.5 or 4 or 4.5 or 5 or 6 or 8 or 10 or 其它长度 |
| 光纤型号 | 100/0.22 or 200/0.37 or 300/0.37 or 400/0.37 or 200/0.50 or 400/0.50 |
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